About Synergo(R) RITE Bladder Cancer
SYNERGO RITE - RADIOFREQUENCY-INDUCED THERMOCHEMOTHERAPEUTIC EFFECT
FOR THE TREATMENT OF NON-MUSCLE INVASIVE BLADDER CANCER
The Synergo System is a computer-embedded intravesical irrigation system combined with an energy-delivering unit. The System includes an RF generator that delivers radio-frequency (radiation) energy at 915 MHz, a drug circulating unit, and a microprocessor with application specific software.
The user interface consists of a computer, monitor with touch screen, keyboard, and bar-code reader. Application specific software monitors and records treatment parameters during an actual session and provides a user interface that instantly alerts the user if parameters are out-of-range.
A sterile triple lumen, silicone, transurethral Foley catheter is used for drug intravesical instillation. It has thermocouples for bladder wall temperature monitoring, and an RF antenna that radiates the bladder walls, causing phenotypical changes selectively in cancerous cells, creates membrane micro-poring (“Tunnelling Nano-Tubes”) and metabolic changes in these cells to increase the uptake of the drug, enhances drug mobility (becomes an active diffusion) through Foucault currents, and last but not least, generates heat at the target tissue at the desired, controlled temperature (hyperthermia) which is a synergistic protagonist.
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