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Direct Coombs Test Why is desired? 1. in the diagnosis of autoimmune diseases: diagnosis when the desired antibodies against erythrocyte antigens occur. Autoimmune diseases, lymphoma and chronic lymphocytic leukemia and other similar diseases may occur this auto antibodies 2.Ann to the investigation of infant blood group incompatibility: the baby's father, can now be inherited antigens found on red blood cells of the mother. During pregnancy or baby's birth event that some cells of the placenta, leaving the mother passes into the bloodstream, on erythrocytes of maternal erythrocytes baby may be exposed to foreign antigens. Mothers can begin to create antibodies against these foreign RBC antigens. This is often the first baby is not unlike the later baby in the late placenta of the mother's antibodies to the baby's red blood cell adheres can cause hemolytic disease of the newborn have them hemolysis. Direct Coombs made in the case of a baby's blood test (DAT test) will determine the baby's maternal antibody that binds to erythrocytes. After the transplant 3rd ability: to create multiple times, especially those with antibodies to erythrocyte transfusion will be exposed to a greater number of red blood cell antigens are more likely. Are formed antibodies against erythrocyte antigens by direct Coombs test, and it will be understood that this antibody binds to erythrocytes transfused donor.